Cruise from California through the Panama Canal, one of the man-made wonders of the world. The canal is 100 years old but is still an awe inspiring engineering feat, and the best way to experience it is on a cruise.
Panama Canal cruises depart from Los Angeles, San Diego or San Francisco. They finish in Miami, Fort Lauderdale, Tampa or New York.
On your journey you'll visit tropical ports in countries like Mexico, Costa Rica and Colombia.
16-night Panama Canal cruise on Regent Seven Seas. One-way from Los Angeles to Miami (Florida). Visit Catalina Island (California), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2023 departure: January 5.
15-day Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2023 departure: January 17.
14-day Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Cartagena (Colombia) and Half Moon Cay (Bahamas).
• 2023 departure: January 21.
15-day Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), San Juan del Sur (Nicaragua), Puntarenas (Costa Rica), Panama City (Panama) and Cartagena (Colombia).
• 2023 departure: January 27.
15-day Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2023 departure: February 16.
14-day Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Cartagena (Colombia) and Half Moon Cay (Bahamas).
• 2023 departure: February 18.
15-day Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), San Juan del Sur (Nicaragua), Puntarenas (Costa Rica), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2023 departure: February 24.
15-day Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2023 departure: April 1.
14-day Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Cartagena (Colombia) and Half Moon Cay (Bahamas).
• 2023 departure: April 4.
15-day Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2023 departure: May 11.
16-night Panama Canal cruise on Cunard. One-way from San Francisco to Fort Lauderdale (Florida). Visit Los Angeles (California), Cabo San Lucas (Mexico), Puntarenas (Costa Rica), the Panama Canal and Oranjsestad (Aruba).
• 2023 departure: August 20.
16-day Panama Canal cruise on Royal Caribbean. One-way from San Diego to Tampa (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicaragua), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2023 departure: October 7.
19-night Panama Canal cruise on Norwegian. One-way from San Francisco to Miami (Florida). Visit Los Angeles (California), Cabo San Lucas (Mexico), Mazatlan (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2023 departure: October 31.
16-day Panama Canal cruise on Oceania. One-way from Los Angeles to Miami (Florida). Visit Ensenada (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2023 departure: November 3.
15-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama) and Cartagena (Colombia).
• 2023 departure: November 19.
14-day Panama Canal cruise on Royal Caribbean. One-way from Los Angeles to Miami (Florida). Visit Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), Grand Cayman (Cayman Islands) and Cozumel (Mexico).
• 2023 departure: November 21.
14-night Panama Canal cruise on Disney. One-way from San Diego to Galveston (Texas). Visit Puerto Vallarta (Mexico), the Panama Canal, Cartagena (Colombia), Grand Cayman (Cayman Islands) and Cozumel (Mexico).
• 2023 departure: December 3.
15-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: January 7.
16-night Panama Canal cruise on Regent Seven Seas. One-way from Los Angeles to Miami (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: January 8.
15-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama) and Cartagena (Colombia).
• 2024 departure: January 12.
15-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
• 2024 departure: January 19.
15-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: February 6.
15-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
• 2024 departure: April 6.
15-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: May 9.
15-night Panama Canal cruise on Celebrity. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: September 19.
16-night Panama Canal cruise on Princess. One-way from San Francisco to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: September 28.
14-night Panama Canal cruise on Royal Caribbean. One-way from Los Angeles to New Orleans (Louisiana). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2024 departure: September 28.
15-night Panama Canal cruise on Carnival. One-way from San Francisco to Galveston (Texas). Visit Cabo San Lucas (Mexico), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2024 departure: October 1.
16-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puerto Caldera (Costa Rica), the Panama Canal, and Aruba.
• 2024 departure: October 4.
16-night Panama Canal cruise on Royal Caribbean. One-way from Los Angeles to Tampa (Florida). Visit Cabo San Lucas (Mexico), Mazatlan (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: October 5.
16-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puerto Caldera (Costa Rica), the Panama Canal, and Aruba.
• 2024 departure: October 10.
17-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Tampa (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Zihuatanejo (Mexico), Puerto Chiapas (Mexico), Acajutla (El Salvador), San Juan del Sur (Nicaragua), Puntarenas (Costa Rica), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: November 7.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2024 departure: November 17.
15-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama) and Cartagena (Colombia).
• 2024 departure: December 6.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2024 departure: December 19.
